A new model of Notch signaling: Control of Notch receptor cis-inhibition via Notch ligand dimers
D. Chen, Z. Forghany, X. Liu, H. Wang, R. Merks, D. Baker
This study demonstrates that Notch ligand dimers mediate cis-inhibition of Notch receptor activity, introducing a new model of Notch signaling that distinguishes between ligand monomer-driven transactivation and dimer-mediated cis-inhibition.
bioRxiv · May 9, 2022 · PreprintCell Biology