Hippocampal Concentrations Drive Seizures in a Rat Model for Cefepime-induced Neurotoxicity
E. Lesnicki, G. Pais, S. Marianski, K. Valdez, Z. Gibson, J. Christopher, M. H. Scheetz
This study identifies hippocampal cefepime concentrations as a threshold for neurotoxicity in rats, linking plasma exposure to seizure onset.
bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology