Author

G. Pais

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 7 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:rat· 7 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. H. Scheetz· 7 shared J. Chang· 4 shared K. Valdez· 4 shared S. Marianski· 4 shared J. Liu· 3 shared E. F. Barreto· 2 shared E. Lesnicki· 2 shared J. N. O'Donnell· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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7 shared papersPharmacology & Toxicology

M. H. Scheetz

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Author profile →

8 papers

Recent·Most cited

Iohexol-measured glomerular filtration rate and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model

J. Chang, G. Pais, S. Marianski, K. Valdez, E. Lesnicki, E. F. Barreto, N. J. Rhodes, P. R. Yarnold, M. H. Scheetz

This study compares kidney function and injury biomarkers in rats treated with vancomycin, piperacillin-tazobactam, or both, finding no additive nephrotoxicity with the combination.

bioRxiv · Mar 9, 2023Pharmacology & Toxicology

Impact of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a translational rat model

J. Chang, G. Pais, P. L. Engel, P. Klimek, S. Marianski, K. Valdez, M. H. Scheetz

This study examines the effects of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a rat model, finding that higher doses correlate with greater kidney injury.

bioRxiv · Sep 26, 2022Pharmacology & Toxicology

Hippocampal Concentrations Drive Seizures in a Rat Model for Cefepime-induced Neurotoxicity

E. Lesnicki, G. Pais, S. Marianski, K. Valdez, Z. Gibson, J. Christopher, M. H. Scheetz

This study identifies hippocampal cefepime concentrations as a threshold for neurotoxicity in rats, linking plasma exposure to seizure onset.

bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology

Glomerular function and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model.

J. Chang, G. Pais, K. Valdez, S. Marianski, E. F. Barreto, M. H. Scheetz

This study compares glomerular function and urinary biomarkers in rats treated with vancomycin alone versus vancomycin plus piperacillin-tazobactam, finding no worsening of kidney function with the combination.

bioRxiv · Nov 8, 2021Pharmacology & Toxicology

Urinary Metabolomics from a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury

E. Locci, J. Liu, G. Pais, A. Chighine, D. A. Kahnamoei, T. Xanthos, A. Chalkias, A. Lee, A. Hauser, J. Chang, N. Rhodes, E. d'Aloja, M. H. Scheetz

This study uses urinary metabolomics in a rat model to show that taurine levels increase on day 1 of polymyxin B treatment and correlate with kidney injury markers.

bioRxiv · May 21, 2021Pharmacology & Toxicology

Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships

M. H. Scheetz, G. Pais, T. Lodise, S. Tong, J. Davis, J. N. O'Donnell, J. Liu, M. Neely, W. Prozialeck, P. Lamar, N. J. Rhodes, T. Holland

The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology

Suppression of endothelial miR-22-3p mediates non-small cell lung cancer cell-induced angiogenesis

Y. Gu, G. Pais, V. Becker, C. Körbel, E. Ampofo, E. Ebert, J. Hohneck, N. Ludwig, E. Meese, R. M. Bohle, Y. Zhao, M. D. Menger, M. W. Laschke

The paper shows that reduced endothelial miR-22-3p in NSCLC tissues promotes angiogenesis by inhibiting SIRT1 and FGFR1, leading to AKT/mTOR inactivation and tumor growth.

bioRxiv · Apr 4, 2021Cancer Biology

The Pharmacodynamic-Toxicodynamic Relationship of AUC and CMAX in Vancomycin Induced Kidney Injury in an Animal Model

S. Avedissian, G. Pais, J. Liu, J. N. O'Donnell, T. Lodise, M. Neely, W. Prozialeck, P. Lamar, L. Becher, M. H. Scheetz

This study investigates the pharmacodynamic-toxicodynamic relationship of vancomycin-induced kidney injury in rats, finding that peak concentrations and fewer daily doses correlate with increased kidney injury.

bioRxiv · Aug 27, 2020Pharmacology & Toxicology