Author

K. Valdez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Organism:rat· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Pais· 4 shared M. H. Scheetz· 4 shared S. Marianski· 4 shared J. Chang· 3 shared E. F. Barreto· 2 shared E. Lesnicki· 2 shared J. Christopher· 1 shared N. J. Rhodes· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersPharmacology & Toxicology

G. Pais

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4 papers

Recent·Most cited

Iohexol-measured glomerular filtration rate and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model

J. Chang, G. Pais, S. Marianski, K. Valdez, E. Lesnicki, E. F. Barreto, N. J. Rhodes, P. R. Yarnold, M. H. Scheetz

This study compares kidney function and injury biomarkers in rats treated with vancomycin, piperacillin-tazobactam, or both, finding no additive nephrotoxicity with the combination.

bioRxiv · Mar 9, 2023Pharmacology & Toxicology

Impact of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a translational rat model

J. Chang, G. Pais, P. L. Engel, P. Klimek, S. Marianski, K. Valdez, M. H. Scheetz

This study examines the effects of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a rat model, finding that higher doses correlate with greater kidney injury.

bioRxiv · Sep 26, 2022Pharmacology & Toxicology

Hippocampal Concentrations Drive Seizures in a Rat Model for Cefepime-induced Neurotoxicity

E. Lesnicki, G. Pais, S. Marianski, K. Valdez, Z. Gibson, J. Christopher, M. H. Scheetz

This study identifies hippocampal cefepime concentrations as a threshold for neurotoxicity in rats, linking plasma exposure to seizure onset.

bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology

Glomerular function and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model.

J. Chang, G. Pais, K. Valdez, S. Marianski, E. F. Barreto, M. H. Scheetz

This study compares glomerular function and urinary biomarkers in rats treated with vancomycin alone versus vancomycin plus piperacillin-tazobactam, finding no worsening of kidney function with the combination.

bioRxiv · Nov 8, 2021Pharmacology & Toxicology