Author

Z. J. Frangos

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

K. A. Wilson· 1 shared M. L. O'Mara· 1 shared R. J. Vandenberg· 1 shared S. N. Mostyn· 1 shared S. Shimmon· 1 shared T. Rawling· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

K. A. Wilson

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1 paper

Recent·Most cited

The inhibitory activity of glycine transporter 2 targeting bioactive lipid analgesics are influenced by formation of a deep lipid cavity

K. A. Wilson, S. N. Mostyn, Z. J. Frangos, S. Shimmon, T. Rawling, R. J. Vandenberg, M. L. O'Mara

This study investigates how N-acyl amino acids inhibit GlyT2 by binding to an allosteric site, showing that stereochemistry, tail length, and double bond position enhance inhibition through deep penetration into the binding pocket.

bioRxiv · Sep 10, 2020 · PreprintBiochemistry