A chimeric nuclease substitutes CRISPR-Cas: A phage weaponizes laterally acquired specificity to destroy subviral parasites
Z. K. Barth, M. H. T. Nguyen, K. Seed
The paper identifies a chimeric endonuclease in bacteriophage ICP1 that provides immunity against PLE mobile elements by cleaving their replication origins.
bioRxiv · Feb 21, 2021Microbiology