Maximal interferon induction by influenza lacking NS1 is infrequent owing to requirements for replication and export
A. C. Vicary, M. Mendes, S. Swaminath, A. Lekbua, J. Reddan, Z. K. Rodriguez, A. B. Russell
The paper investigates how genetic and phenotypic variation in influenza A virus lacking NS1 correlates with interferon production, finding that high replication and defective viral genomes are required for interferon induction despite the absence of NS1.
bioRxiv · Oct 24, 2022 · PreprintMicrobiology