Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy
N. K. Horvat, I. Karpovsky, M. Wyatt, M. A. Hall, M. Phillips, C. Herting, J. Hammons, Z. Mahdi, R. A. Moffitt, C. Paulos, G. B. Lesinski
This study compares two orthotopic PDAC mouse models to evaluate their suitability for studying adoptive T cell therapy, finding that the MT-5 model better replicates the stromal features of human PDAC.
bioRxiv · Sep 7, 2023 · PreprintCancer Biology