Comprehensive Fitness Landscape of a Multi-Geometry Protein Capsid Informs Machine Learning Models of Assembly
D. D. Brauer, C. B. Santiago, Z. N. Merz, E. McCarthy, D. Tullman-Ercek, M. B. Francis
The paper generates fitness landscapes for two VLP capsid geometries and uses them to train machine learning models for predicting mutational effects on assembly.
bioRxiv · Dec 21, 2021 · PreprintBioengineering