Author

D. D. Brauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Schepartz· 2 shared M. B. Francis· 2 shared A. Tytla· 1 shared A. Vazquez· 1 shared C. B. Santiago· 1 shared D. Tullman-Ercek· 1 shared E. McCarthy· 1 shared J. A. Walker· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

A. Schepartz

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Author profile →

3 papers

Recent·Most cited

Requirements for efficient endosomal escape by designed mini-proteins

J. Giudice, D. D. Brauer, M. Zoltek, A. Vazquez, M. J. S. Kelly, A. Schepartz

This paper identifies the requirements for efficient endosomal escape by ZF5.3, a mini-protein, showing pH-induced unfolding and lipid-BMP interaction are critical for its function.

bioRxiv · Apr 5, 2024 · PreprintBiochemistry

Redirecting RiPP biosynthetic enzymes to proteins and backbone-modified substrates

J. A. Walker, N. Hamlish, A. Tytla, D. D. Brauer, M. B. Francis, A. Schepartz

This paper demonstrates that RiPP enzymes can incorporate backbone-modified monomers into proteins, creating sequence-defined chemical polymers with diverse non-alpha-amino acid subunits.

bioRxiv · Jan 5, 2022Biochemistry

Comprehensive Fitness Landscape of a Multi-Geometry Protein Capsid Informs Machine Learning Models of Assembly

D. D. Brauer, C. B. Santiago, Z. N. Merz, E. McCarthy, D. Tullman-Ercek, M. B. Francis

The paper generates fitness landscapes for two VLP capsid geometries and uses them to train machine learning models for predicting mutational effects on assembly.

bioRxiv · Dec 21, 2021 · PreprintBioengineering