Author

M. B. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein design· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Schepartz· 2 shared D. D. Brauer· 2 shared D. Tullman-Ercek· 2 shared J. A. Walker· 2 shared A. J. Bischoff· 1 shared A. Tytla· 1 shared B. C. Ikwuagwu· 1 shared C. B. Santiago· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

A. Schepartz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aminobenzoic acid derivatives obstruct induced fit in the catalytic center of the ribosome

C. Majumdar, J. A. Walker, M. B. Francis, A. Schepartz, J. H. D. Cate

This study reports cryo-EM structures of E. coli ribosomes with aminobenzoic acid derivatives, revealing how steric blocking and proton wire disruption affect amide bond formation efficiency.

bioRxiv · Jan 25, 2023Biophysics

A membrane-associated light harvesting model is enabled by functionalized assemblies of gene-doubled TMV proteins

J. Dai, K. B. Wilhelm, A. J. Bischoff, J. H. Pereira, M. T. Dedeo, D. M. Garcia-Almedina, P. D. Adams, J. T. Groves, M. B. Francis

This paper develops a synthetic light harvesting model using modified TMV proteins attached to lipid bilayers, enabling dynamic energy transfer studies.

bioRxiv · Sep 8, 2022Bioengineering

Redirecting RiPP biosynthetic enzymes to proteins and backbone-modified substrates

J. A. Walker, N. Hamlish, A. Tytla, D. D. Brauer, M. B. Francis, A. Schepartz

This paper demonstrates that RiPP enzymes can incorporate backbone-modified monomers into proteins, creating sequence-defined chemical polymers with diverse non-alpha-amino acid subunits.

bioRxiv · Jan 5, 2022Biochemistry

Comprehensive Fitness Landscape of a Multi-Geometry Protein Capsid Informs Machine Learning Models of Assembly

D. D. Brauer, C. B. Santiago, Z. N. Merz, E. McCarthy, D. Tullman-Ercek, M. B. Francis

The paper generates fitness landscapes for two VLP capsid geometries and uses them to train machine learning models for predicting mutational effects on assembly.

bioRxiv · Dec 21, 2021 · PreprintBioengineering

Engineering a virus-like particle to display peptide insertions using an apparent fitness landscape

S. A. Robinson, E. C. Hartman, B. C. Ikwuagwu, M. B. Francis, D. Tullman-Ercek

The paper engineers MS2 virus-like particles with peptide insertions using SyMAPS to map insertion effects on capsid assembly and function.

bioRxiv · Jun 23, 2020Biochemistry