IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D
Z. Xin, Z. Qing, L. D. Yong, L. Y. Meng, X. Qing, L. X. Hong, L. Wen, Z. Min, L. Li, Y. Lu, J. Cheng, Y. Chen
This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.
bioRxiv · Oct 12, 2022 · PreprintCell Biology