Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.
Z. Radvanyi, E. J. Yoo, P. Kandasamy, A. Salas-Bastos, S. Monnerat, J. Refardt, M. Christ-Crain, H. Hayashi, Y. Kondo, J. Jantsch, I. Rubio-Aliaga, L. Sommer, C. A. Wagner, M. A. Hediger, H. M. Kwon, , G. Pathare
This study shows that extracellular sodium concentration directly regulates FGF23 synthesis in osteoblast-like cells and links this regulation to NFAT5 expression, with implications for disease states like hyponatremia.
bioRxiv · Jun 23, 2023Physiology