H. Hayashi

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.

This study shows that extracellular sodium concentration directly regulates FGF23 synthesis in osteoblast-like cells and links this regulation to NFAT5 expression, with implications for disease states like hyponatremia.

Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

The paper investigates how early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination correlates with sustained anti-S antibody levels.

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

Preclinical study of DNA vaccines targeting SARS-CoV-2

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan

This study analyzes B cell epitopes and neutralizing activity in COVID-19 patients to identify potential vaccine targets.

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length

This study shows that Ran-GTP is not essential for NuMA activation in spindle pole focusing but is required for HURP polarization and spindle length regulation during prometaphase.

Capsicum cultivated under adverse conditions in Southern Japan produces higher concentrations of antioxidants and pungent components

This study shows that Capsicum grown in sandy soils in Southern Japan has higher antioxidant and pungent component levels compared to traditional tropical-origin peppers.

Three-dimensional culture of chicken primordial germ cells in chemically defined media containing the functional polymer FP003

This study develops a 3D culture system for chicken primordial germ cells using chemically defined media, enabling scalable expansion and maintenance of cellular properties.

The unconventional kinetoplastid kinetochore protein KKT4 tracks with dynamic microtubule tips

This study identifies KKT4, a kinetoplastid kinetochore protein that binds and tracks with microtubule tips, enabling chromosome segregation despite lacking homology to known microtubule-binding domains.

Degradation of cyclin B is critical for nuclear division in Trypanosoma brucei

This study shows that CYC6 cyclin degradation controls nuclear division timing in T. brucei without a spindle checkpoint, allowing metaphase arrest without cytokinesis prevention.

A novel mechanism of “metal gel-shift” by histidine-rich Ni2+-binding Hpn protein from Helicobacter pylori strain SS1

The paper investigates the 'gel shifting' phenomenon in the Ni2+-binding Hpn protein from Helicobacter pylori, showing that metal binding and gel concentration affect migration patterns.