Author

M. A. Hediger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Augustynek· 2 shared P. Kandasamy· 2 shared A. Salas-Bastos· 1 shared A. van Drogen· 1 shared B. Snijder· 1 shared B. Wollscheid· 1 shared C. A. Wagner· 1 shared C. Peinelt· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

B. Augustynek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.

Z. Radvanyi, E. J. Yoo, P. Kandasamy, A. Salas-Bastos, S. Monnerat, J. Refardt, M. Christ-Crain, H. Hayashi, Y. Kondo, J. Jantsch, I. Rubio-Aliaga, L. Sommer, C. A. Wagner, M. A. Hediger, H. M. Kwon, , G. Pathare

This study shows that extracellular sodium concentration directly regulates FGF23 synthesis in osteoblast-like cells and links this regulation to NFAT5 expression, with implications for disease states like hyponatremia.

bioRxiv · Jun 23, 2023Physiology

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

S. Lee, T. Weiss, M. Buehler, J. Mena, Z. Lottenbach, R. Wegmann, M. Sun, M. Bihl, B. Augustynek, S. Baumann, S. Goetze, A. van Drogen, P. Pedrioli, D. Kirschenbaum, F. Vasella, , B. Snijder

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

bioRxiv · Oct 7, 2022 · PreprintCancer Biology

Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state

B. Augustynek, G. Gyimesi, J. Dernic, M. Sallinger, G. Albano, G. J. Klesse, P. Kandasamy, H. Grabmayr, I. Frischauf, D. G. Fuster, C. Peinelt, M. A. Hediger, R. Bhardwaj

The paper investigates the gating mechanisms of Orai calcium channel paralogs by analyzing constitutively active mutants that mimic STIM1-gated states, revealing differences in conservation across paralogs.

bioRxiv · Oct 26, 2021 · PreprintCell Biology