Human induced pluripotent stem cell-derived neuroectodermal epithelial cells mistaken for blood-brain barrier-forming endothelial cells
T. M. Lu, D. Redmond, T. Magdeldin, D. T. Nguyen, A. Snead, A. Sproul, J. Xiang, H. A. Fine, K. Shido, Z. Rosenwaks, S. Rafii, D. Agalliu, R. Lis
The paper identifies human iBMECs as EpCAM+ neuroectodermal epithelial cells rather than BBB-forming endothelial cells, showing that ETS TFs can reprogram them toward a vascular BBB in vitro.
bioRxiv · Jul 11, 2019Cell Biology