D. T. Nguyen

β-Catenin associates with a Wnt signaling mRNA network in myeloid cells through canonical RBP binding.

The paper identifies β-catenin-associated mRNAs in myeloid cells through RIP-seq and shows MSI2 interacts with LEF1 mRNA, regulating Wnt signaling and HSPC expansion.

The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

This study shows that HIV-1 capsid acts as a nanoscale container for reverse transcription, with NERT activity dependent on gp41 and not requiring IP6 or a mature capsid.

Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups

This study discovers a new class of macrocyclic peptides by mining genomes for biosynthetic gene clusters, revealing novel enzymatic modifications involving a cytochrome P450 and other enzymes.

Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

Mfsd7b facilitates choline uptake and missense mutations affect choline transport function

This study identifies MFSD7b as a choline transporter and shows that missense mutations impair its function.

Genotypic and resistance profile analysis of two oat crown rust differential sets urge coordination and standardisation

The paper compares virulence profiles of Pca isolates using two differential sets and identifies discrepancies, validating molecular markers for rust resistance gene stacking in oat.

Virulence patterns of oat crown rust in Australia - season 2022

The paper characterizes virulence patterns of Puccinia coronata f. sp. avenae isolates from Australia, finding higher virulence diversity in Eastern Australia compared to Western Australia.

mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides

The paper discovers and characterizes two novel biaryl-containing lasso peptides, revealing new structural modifications and biosynthetic enzymes.

Three-Dimensional Bioconjugated Liquid-Like Solid (LLS) Enhance Characterization of Solid Tumor - Chimeric Antigen Receptor T cell Interactions

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.

Immune Checkpoint Activity Regulates Polycystic Kidney Disease Progression

This study investigates immune checkpoint activity in ADPKD, finding that dual checkpoint inhibition improves disease outcomes in adult-onset models.

Multiple generations of antibiotic exposure and isolation influence host fitness and the microbiome in a model zooplankton species

This study examines how multiple generations of antibiotic exposure and isolation affect host fitness and microbiome composition in Daphnia magna, finding rapid microbiome recovery but diversity loss due to isolation.

The ATF6β-calreticulin axis protects hippocampal neurons against endoplasmic reticulum stress and excitotoxicity

This study shows that ATF6β-calreticulin protects hippocampal neurons from ER stress and excitotoxicity by maintaining Ca2+ homeostasis.

In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response

This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.

Prostaglandin receptor EP2 is a novel molecular target for high-risk neuroblastoma

This study identifies EP2 as a key PGE2 receptor promoting neuroblastoma growth and shows that targeting it with small-molecule antagonists inhibits tumor growth in mice.

Human induced pluripotent stem cell-derived neuroectodermal epithelial cells mistaken for blood-brain barrier-forming endothelial cells

The paper identifies human iBMECs as EpCAM+ neuroectodermal epithelial cells rather than BBB-forming endothelial cells, showing that ETS TFs can reprogram them toward a vascular BBB in vitro.

A Novel Melatonergic Signature Predicts Reccurence Risk and Therapeutic Response in Breast Cancer Patients

The paper identifies an ASMT gene signature that predicts recurrence risk and therapeutic response in breast cancer patients, showing improved outcomes with melatonin and tamoxifen combination therapy.