J. Xiang

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates.

The paper identifies secreted proteins by comparing their abundance in conditioned media and cell lysates, finding proteins enriched in media as potential secreted candidates.

A CRISPR-based instant DNA repositioning system and the early intranuclear life of HSV-1

This paper introduces CRISPR-nuPin, a system to reposition viral DNA to the nuclear periphery, revealing how HSV-1 genome localization affects transcription and pathogenesis during early infection.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

The paper evaluates the neutralization efficacy of inactivated and RBD-subunit vaccines against SARS-CoV-2 B.1.617 and B.1.1.7 variants using a pseudovirus-based assay.

The role of AUX1 during lateral root development in the domestication of the model C4 grass Setaria italica

This study identifies SiAUX1 as critical for lateral root development in Setaria italica, revealing its role in cell volume distribution and vascular strand formation through mutant analysis and RNAseq.

Identification of age and ethnicity specific gene expression biomarkers for immune aging

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

Intranasal administration of SARS-CoV-2 neutralizing human antibody prevents infection in mice

A Fc-modified human antibody prevents SARS-CoV-2 viral infection via nasal administration.

Detection of melanin-mediated false-positive for BaxΔ2 immunohistochemical staining in human skin tissue

The paper identifies that melanin in skin tissue causes false-positive BaxΔ2 immunostaining in the epidermis, but not in dermal connective tissues.

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

A multiplexed, automated evolution pipeline enablesscalable discovery and characterization of biosensors

This paper introduces DRIVER, a method for rapidly evolving RNA biosensors, and validates them for detecting small molecules and regulating gene expression in yeast.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Rotten-skin disease significantly changed giant spiny frog(Paa spinosa) gut microbiota

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

Human induced pluripotent stem cell-derived neuroectodermal epithelial cells mistaken for blood-brain barrier-forming endothelial cells

The paper identifies human iBMECs as EpCAM+ neuroectodermal epithelial cells rather than BBB-forming endothelial cells, showing that ETS TFs can reprogram them toward a vascular BBB in vitro.

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

This study identifies SURF4 as a cargo receptor that facilitates PCSK9 secretion by linking it to COPII components and confirming its functional role through multiple experimental approaches.

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human Cerebellum

The paper reports the presence of BaxΔ2 protein in human cerebellar tissues, with varying expression levels across Purkinje cells and associated genetic mutations.