Impact of sickle cell trait hemoglobin in Plasmodium falciparum-infected erythrocytes
Z. Seidu, M. F. Ofori, L. Hviid, M. Lopez-Perez
This study investigates how PfEMP1 expression changes in Plasmodium falciparum parasites cultured in sickle cell trait (HbAS) versus normal (HbAA) erythrocytes, finding reduced parasite survival and PfEMP1 expression in HbAS IEs, with increased pfsa2 transcription.
bioRxiv · Jul 28, 2023 · PreprintMicrobiology