Author

Z. Sethna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:CITE-seq· 2 Research Focus:clustering· 2 Approach:deep learning· 2

Frequent Co-Authors

T. Mora· 4 shared Y. Elhanati· 4 shared A. M. Walczak· 3 shared C. G. Callan· 2 shared G. Isacchini· 2 shared A. Levine· 1 shared A. Nourmohammad· 1 shared A. Walczak· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

T. Mora

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Author profile →

4 papers

Recent·Most cited

On generative models of T-cell receptor sequences

G. Isacchini, Z. Sethna, Y. Elhanati, A. Nourmohammad, A. M. Walczak, T. Mora

This study compares two models for predicting TCR sequence probabilities, finding that a knowledge-guided approach outperforms a deep learning model in accuracy, interpretability, and efficiency.

bioRxiv · Mar 14, 2020Immunology

Population variability in the generation and thymic selection of T-cell repertoires

Z. Sethna, G. Isacchini, T. Dupic, T. Mora, A. M. Walczak, Y. Elhanati

The paper introduces SONIA, a tool to analyze TCR repertoire variability, finding that most variability stems from VDJ generation and that inter-individual variance is small compared to intra-individual variance.

bioRxiv · Jan 8, 2020Immunology

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

Y. Elhanati, Z. Sethna, C. G. Callan, T. Mora, A. M. Walczak

The paper develops a model to predict TCR repertoire sharing by accounting for recombination biases and thymic selection, introducing a classifier that performs well across cohort sizes.

bioRxiv · Mar 2, 2018Immunology

Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence

Z. Sethna, Y. Elhanati, C. S. Dudgeon, C. G. Callan, A. Levine, T. Mora, A. Walczak

The paper analyzes T cell repertoires in mice to show age-related increases in VDJ recombination diversity and similar selection effects in thymus and blood.

bioRxiv · Nov 10, 2016Immunology