A. Walczak

Learning predictive signatures of HLA type from T-cell repertoires

The paper develops a model to predict HLA types from TCR repertoires using associations inferred from HLA-typed donors.

Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals

The paper analyzes human TCR repertoires across thymic development stages and individuals, finding that inter-individual variability persists through maturation and that local sequence similarity correlates with cell type information.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

This study uses an in situ lineage tracing method to show that aging increases the number of HSPCs contributing to myelopoiesis, not their individual output.

Probabilities of HIV-1 bNAb development in healthy and chronically infected individuals

The paper uses sequence analysis to predict the likelihood of HIV-1 broadly neutralizing antibody (bNAb) development in healthy and infected individuals, finding that chronic infection is not required for bNAb generation.

Contribution of resident and circulating precursors to tumor-infiltrating CD8+ T cell populations in non-small cell lung cancer patients

The paper identifies two CD8+ TIL subpopulations in NSCLC, one circulating and one resident, which transition into terminally differentiated cells through a unique state.

Optimal prediction with resource constraints using the information bottleneck

The paper investigates optimal prediction under resource constraints by analyzing trade-offs between encoding past information and predicting future inputs in different dynamic systems.

Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins

The paper develops a statistical framework to detect TCR clone changes in vaccinated twins and finds convergent yet personalized TCR responses.

Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence

The paper analyzes T cell repertoires in mice to show age-related increases in VDJ recombination diversity and similar selection effects in thymus and blood.