Impact of non-proteinogenic amino acid norvaline and proteinogenic valine misincorporation on a secondary structure of a model peptide
Z. Skibola, I. Gruic-Sovulj, A. Marsavelski
The paper investigates how norvaline and valine misincorporation at isoleucine positions affects a model peptide's secondary structure, showing norvaline causes greater disruption to β-sheet structures, contributing to higher toxicity.
bioRxiv · Sep 26, 2022Biochemistry