Author

I. Gruic-Sovulj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:biophysical modeling· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Marsavelski· 2 shared N. Ban· 2 shared V. Zanki· 2 shared A. Brkic· 1 shared A. Kahana· 1 shared B. Bozic· 1 shared D. Despotovic· 1 shared D. S. Tawfik· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Marsavelski

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif

A. Brkic, M. Leibundgut, J. Jablonska, V. Zanki, Z. Car, V. Petrovic-Perokovic, A. Marsavelski, N. Ban, I. Gruic-Sovulj

The paper identifies a structural basis for mupirocin resistance in IleRS2, showing that an altered HIGH motif leads to hyper-resistance.

bioRxiv · Jan 31, 2023Biochemistry

Impact of non-proteinogenic amino acid norvaline and proteinogenic valine misincorporation on a secondary structure of a model peptide

Z. Skibola, I. Gruic-Sovulj, A. Marsavelski

The paper investigates how norvaline and valine misincorporation at isoleucine positions affects a model peptide's secondary structure, showing norvaline causes greater disruption to β-sheet structures, contributing to higher toxicity.

bioRxiv · Sep 26, 2022Biochemistry

A pair of isoleucyl-tRNA synthetases in Bacilli fulfill complementary roles to keep fast translation and provide antibiotic resistance

V. Zanki, B. Bozic, M. Mocibob, N. Ban, I. Gruic-Sovulj

This study shows that Bacillus species use two IleRS enzymes with distinct roles: one for fast translation and one for antibiotic resistance.

bioRxiv · Feb 9, 2022Biochemistry

Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases

I. Zivkovic, K. Ivkovic, N. Cvetesic, I. Gruic-Sovulj

The paper shows that the editing domain of class I AARSs preferentially hydrolyzes misaminoacyl-tRNAs to prevent errors, revealing a mechanism of negative catalysis that safeguards cognate tRNAs.

bioRxiv · Oct 18, 2021Biochemistry

Polyamines Mediate Folding of Primordial Hyper-Acidic Helical Proteins

D. Despotovic, L. M. Longo, E. Aharon, A. Kahana, T. Scherf, I. Gruic-Sovulj, D. S. Tawfik

This study shows polyamines induce folding of a hyper-acidic ancestral protein, suggesting they may have functioned as chemical chaperones in early life.

bioRxiv · Oct 1, 2020Evolutionary Biology