Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding
M.-T. Cheng, Y. Chen, Z.-P. Chen, C.-Z. Zhou, W.-T. Hou, Y. Chen
This study reveals the structural mechanism of ATP8B1 activation by substrate binding, showing an autoinhibited state that is released upon phosphatidylserine binding.
bioRxiv · Nov 7, 2021Biochemistry