Author

C.-Z. Zhou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Y. Chen· 6 shared W.-T. Hou· 4 shared L. Wang· 2 shared Q. Li· 2 shared Y.-L. Jiang· 2 shared A. Basu· 1 shared A. Whitman· 1 shared B. A. Haubrich· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersBiochemistry

Y. Chen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Nonribosomal peptide synthetases require dynamic interaction between modular domains

C.-C. Zhang, Y.-J. Peng, X. Zeng, Y. Chen, C.-Z. Zhou, W. Miao, Y.-L. Jiang

This study investigates the dynamic interaction between the C and A domains in NRPS modules, revealing the role of the RXGR motif in adenylation activity and its prevalence across different NRPSs.

bioRxiv · Nov 13, 2023 · PreprintBiochemistry

PII signal transduction superfamily acts as a valve plug to control bicarbonate and ammonia homeostasis among different bacterial phyla

M. Haffner, W.-T. Hou, O. Mantovani, P. R. Walke, K. Hauf, M. Borisova, M. Hagemann, C.-Z. Zhou, K. Forchhammer, K. A. Selim

The paper identifies SbtB as a PII-like protein that acts as a unidirectional valve to control bicarbonate transport via SbtA in cyanobacteria, with similar mechanisms observed in Bacillus for ammonium transport.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

Structural insights into human ABCC4 mediated transport of platelet agonist and inhibitor

Y. Chen, L. Wang, W.-T. Hou, Z.-H. Zha, K. Xu, C.-Z. Zhou, Q. Li, Y. Chen

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

bioRxiv · Dec 25, 2022 · PreprintBiochemistry

Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding

M.-T. Cheng, Y. Chen, Z.-P. Chen, C.-Z. Zhou, W.-T. Hou, Y. Chen

This study reveals the structural mechanism of ATP8B1 activation by substrate binding, showing an autoinhibited state that is released upon phosphatidylserine binding.

bioRxiv · Nov 7, 2021Biochemistry

Structural basis of substrate recognition and translocation by human ABCD1

Z. Chen, D. Xu, L. Wang, C.-Z. Zhou, W.-T. Hou, Y. Chen

This paper reports cryo-EM structures of human ABCD1 in different states to elucidate its mechanism of substrate recognition, translocation, and release.

bioRxiv · Sep 24, 2021Biophysics

Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system

F. Zhao, X. Lin, K. Cai, Y. Jiang, T. Ni, Y. Chen, J. Feng, S. Dang, C.-Z. Zhou, Q. Zeng

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

bioRxiv · Jul 20, 2021 · PreprintMicrobiology

Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation

B. A. Haubrich, S. Nayyab, C. Williams, A. Whitman, T. Zimmerman, Q. Li, Y. Chen, C.-Z. Zhou, A. Basu, C. W. Reid

The paper identifies a diamide inhibitor of Streptococcus pneumoniae growth and shows that genetic and chemical inactivation of autolysins yield different phenotypic outcomes.

bioRxiv · Sep 16, 2020 · PreprintBiochemistry

Analysis of Structure and function by the LysR-Type Transcriptional Regulator CbbR of Nostoc sp. PCC 7120

H.-x. Xu, S.-J. Han, Y.-L. Jiang, C.-Z. Zhou

This study optimizes conditions for expressing and purifying CbbR from Nostoc sp. PCC 7120, obtains DNA fragments that bind to CbbR, and achieves protein crystallization to facilitate structural analysis.

bioRxiv · Aug 4, 2020 · PreprintBiochemistry