T-regulatory cell protection of progenitor cells from CD4+ T-cell-mediated cytotoxicity is essential for endogenous mouse digit-tip regeneration.
Zachery Beal, Robyn E. Reeve, Elizabeth Hammond, Nadia A Rosenthal, James W. Godwin
The paper shows CD4+ T cells inhibit digit-tip regeneration by attacking progenitor cells, which can be counteracted by T regulatory cells or RANKL.
bioRxiv · Nov 19, 2025 · PreprintDevelopmental Biology