Directed differentiation of EA/TEF patient-derived induced pluripotent stem cells into esophageal epithelial organoids reveal SOX2 dysregulation at the anterior foregut stage
Suleen Raad, Anu David, Mélanie Sagniez, Zakaria Orfi, Nicolas A. Dumont, Martin A. Smith, Christophe C. Faure
The paper differentiates iPSCs from EA/TEF patients and healthy donors into esophageal organoids, identifying SOX2 and NKX2.1 dysregulation as potential causes of foregut compartmentalization defects.
bioRxiv · Feb 14, 2022 · PreprintDevelopmental Biology