Christophe C. Faure

GDNF regenerates the missing enteric nervous system of Hirschsprung mice via non-canonical signaling in diverse subtypes of tissue-resident progenitors

This study shows GDNF regenerates the missing enteric nervous system in Hirschsprung mice through non-canonical signaling in tissue-resident progenitors, suggesting potential for broader therapeutic applications.

Identification and validation of novel candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas

The paper identifies novel risk genes associated with EA/TEF through whole genome sequencing and functional validation using CRISPR-Cas9 in Xenopus.

Directed differentiation of EA/TEF patient-derived induced pluripotent stem cells into esophageal epithelial organoids reveal SOX2 dysregulation at the anterior foregut stage

The paper differentiates iPSCs from EA/TEF patients and healthy donors into esophageal organoids, identifying SOX2 and NKX2.1 dysregulation as potential causes of foregut compartmentalization defects.