Mechanistic Decoding of Pharmacodynamic Intratumoral Heterogeneity: A Pan-Cancer Regulatory Framework
Zhixiang Ren, Yiming Ren, Zeting Li, Shuang Ge, Yaxin Xu, Huan Xu
The paper decodes pharmacodynamic intratumoral heterogeneity by linking single-cell transcriptomes with drug-response profiles across 24 cancer types, identifying regulatory mechanisms driving differential drug responses.
bioRxiv · Oct 5, 2026 · PreprintCancer Biology