Cancer BiologybioRxivPreprint
Mechanistic Decoding of Pharmacodynamic Intratumoral Heterogeneity: A Pan-Cancer Regulatory Framework
Zhixiang Ren, Yiming Ren, Zeting Li…·Huan Xu
The paper decodes pharmacodynamic intratumoral heterogeneity by linking single-cell transcriptomes with drug-response profiles across 24 cancer types, identifying regulatory mechanisms driving differential drug responses.