Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors
Lei An, Shuqing Chen, Guangyao Wu, Chang Liu, Zhenxing Wang, Chunli Wang, Zeyuan Shi, Chenguang Niu, Xiaodong Li, Wenxue Tang, Hongen Xu, Yueqiang Wang
The paper systematically studies the sensitivity of 74,389 EGFR variants to five tyrosine kinase inhibitors using cytotoxicity assays and presents a comprehensive reference for treatment responses.
bioRxiv · Jul 18, 2021 · PreprintGenetics