Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis
Tianhao Li, Gang Wang, Han Zhao, Fuhai Liu, Zhangyuzi Deng, Dingbao Chen, Xin Zhou, Ying Cao, Wei Fu, Haoyue Zhang, Jing Hui Yang
This study shows that estrogen receptor 1 in hepatic stellate cells influences liver fibrosis severity, with ESR1 deletion promoting fibrosis and estradiol reducing it in mice.
Cell Discovery · Apr 15, 2025Peer-reviewedPathology