Function expansion of antitumor transcriptional activator NFE2L1 by the original discovery of its non-transcription factor activity
Lu Qiu, Qiufang Yang, Peng Li, Zhou Xiaowen, Yonghui Yang, Zhou Xiuman, Gou Shanshan, Zhai Wenjie, Guodong Li, Ren Yonggang, Zhao Wenshan, Yahong Wu, Yuanming Qi, Yanfeng Gao
This study discovers the non-transcription factor activity of NFE2L1 in cytoplasm, revealing its tumor suppressive role through Wnt/β-catenin signaling repression, independent of its transcriptional function.
bioRxiv · Oct 8, 2020 · PreprintMolecular Biology