Type III Druantia two-component antiphage defense depends on the DruH-DruE interaction for halting phage DNA cyclization and replication
This study identifies the DruH-DruE two-component system in Mycobacterium smegmatis as a type III Druantia defense mechanism that prevents phage DNA cyclization and replication.
bioRxiv · May 18, 2026 · PreprintMicrobiology