Lesion-Level-Dependent Neuroendocrine Surge Precedes Neuroinflammation and Endoplasmic Reticulum Stress in the Hypothalamus After Spinal Cord Injury: Dual-Cohort Transcriptomic Evidence for a Temporally Ordered AVP Cascade
Lianhua Li, Hong Zeng, Ming Li, Jie Gao, Hua Chen, Bin Cai, Zhi Liu
This study identifies a temporally ordered hypothalamic cascade after spinal cord injury, showing an early AVP surge precedes neuroinflammation and ER stress, with transcriptomic evidence from two rat cohorts.
bioRxiv · Apr 22, 2026 · PreprintNeuroscience