ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing
Yanzhu Wang, Zhimin Zhang, Wei He, Pengyu Wang, Jiang Du, Jinheng Pan, Shan Feng, Jing Huang, Zhejian Ji
The paper shows Ufd1's UT3 domain unfolds ubiquitin in an ATP-independent manner, enabling Cdc48/p97 to process polyubiquitinated substrates.
Nature Structural & Molecular Biology · Sep 10, 2026Peer-reviewedBiophysics