Jiang Du

The paper shows Ufd1's UT3 domain unfolds ubiquitin in an ATP-independent manner, enabling Cdc48/p97 to process polyubiquitinated substrates.

This study identifies nsP3-RBP co-condensation as a mechanism alphaviruses use to sustain replication, showing disruption of these condensates can inhibit viral replication.

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

This study maps clonal lineage commitment pathways of hematopoietic stem cells in vivo, revealing differences in clonal behavior under homeostasis and after hematopoietic depletion.

The paper shows hematopoietic stem cells in mice compensate for functional deficiencies by increasing clonal expansion during lymphopoiesis, maintaining blood supply and influencing blood cell types.