ARIH1 deficiency impairs spatial learning and memory via GIRK2 upregulation in hippocampal CaMKII-expressing neurons in mice
Chunsheng Zhang, Zhiruo Sun, Xiaowen Chen, Huicui Yang, Jiaojiao Chen, Zhong Ding, Xuechu Zhen
This study shows ARIH1 deficiency impairs spatial learning and memory in mice by increasing GIRK2 in hippocampal CaMKII neurons, which can be reversed by GIRK inhibition.
bioRxiv · Mar 10, 2025 · PreprintNeuroscience