Xuechu Zhen

This study shows ARIH1 deficiency impairs spatial learning and memory in mice by increasing GIRK2 in hippocampal CaMKII neurons, which can be reversed by GIRK inhibition.

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.