Author

Zhiyu Zhao

Chinese Academy of Sciences

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Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Chuan CaoiD· 1 shared Fusong JuiD· 1 shared Guoqing LiuiD· 1 shared Haiguang LiuiD· 1 shared Haoran SuniD· 1 shared Liang HeiD· 1 shared Lijun WuiD· 1 shared Pan DengiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Chuan CaoORCID

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1 paper

Recent·Most cited

Accelerating protein engineering with fitness landscape modeling and reinforcement learning

Haoran Sun, Liang He, Pan Deng, Guoqing Liu, Zhiyu Zhao, Yuliang Jiang, Chuan Cao, Fusong Ju, Lijun Wu, Haiguang Liu, Tao Qin, Tie‐Yan Liu

The paper introduces {micro}Protein, a framework combining deep learning and reinforcement learning to predict and discover high-gain protein mutants using single mutation data.

Nature Machine Intelligence · Sep 8, 2025Peer-reviewedSynthetic Biology