Author

Guoqing Liu

Microsoft (United States)ORCID 0009-0005-8512-4049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Chuan CaoiD· 2 shared Haiguang LiuiD· 2 shared Pan DengiD· 2 shared Cuiting Zhong· 1 shared Fusong JuiD· 1 shared Haitao HuangiD· 1 shared Haoran SuniD· 1 shared Liang HeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Chuan CaoORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJul 17, 2026

Reconstructing sequence-grammar trajectories enables interpretable and tunable cis-regulatory element design

Mingqian Ma, Wanjuan Bu, Guoqing Liu…·Zeyu Chen

This paper introduces GO-CRE, a method for designing cell-type-specific cis-regulatory elements by reconstructing sequence-grammar trajectories and using reinforcement learning with predictor guidance.

DOI 10.64898/2026.07.10.737719

humanDNA methylation

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Synthetic BiologyNature Machine IntelligencePeer-reviewedSep 8, 2025

Accelerating protein engineering with fitness landscape modeling and reinforcement learning

Haoran Sun, Liang He, Pan Deng…·Tie‐Yan Liu

The paper introduces {micro}Protein, a framework combining deep learning and reinforcement learning to predict and discover high-gain protein mutants using single mutation data.

16 citationstop 3%

protein sequencedeep learning

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