Fast and reliable association discovery in large-scale microbiome studies and meta-analyses using PALM
Zhoujingpeng Wei, Qilin Hong, Guanhua Chen, Tina V. Hartert, Christian Rosas‐Salazar, Suman R Das, Meghan H. Shilts, Albert M. Levin, Zheng-Zheng Tang
This paper introduces PALM, a quasi-Poisson regression framework for fast and reliable association discovery in large-scale microbiome studies and meta-analyses, showing improved control of false discovery rates and computational efficiency.
bioRxiv · Apr 10, 2026 · PreprintMicrobiology