Computational fluid dynamics enables predictable scale-up of perfusion bioreactors for microvessel production
Pouyan Vatani, Kasinan Suthiwanich, Zidong Han, David A. Romero, Sara Santana Nunes, Cristina H. Amon
This paper uses computational fluid dynamics to guide the scaling of perfusion bioreactors, showing that maintaining interstitial flow ensures reproducible microvessel networks across 30-fold volume increases.
PNAS Nexus · Aug 1, 2026Peer-reviewedBioengineering