Sara Santana Nunes

Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System

This paper develops a scalable bioreactor-based method using growth factors to produce human pluripotent stem cell-derived cardiomyocytes with high purity and yield.

Computational fluid dynamics enables predictable scale-up of perfusion bioreactors for microvessel production

This paper uses computational fluid dynamics to guide the scaling of perfusion bioreactors, showing that maintaining interstitial flow ensures reproducible microvessel networks across 30-fold volume increases.

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo

This study generates human pluripotent stem cell-derived AVN-like pacemaker cells that replicate AVN function in vivo, suggesting their potential as biological conduction bridges for treating AV block.

SGLT2 transcriptomic expression atlas supports a kidney-centric role for empagliflozin's benefits in heart failure

The paper presents a single-cell transcriptomic analysis of SGLT2 expression, showing it is primarily restricted to kidney epithelial cells, supporting a kidney-centric mechanism for SGLT2i benefits in heart failure.

GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation

This study shows that GP2-enriched pancreatic progenitors generate functional beta-like cells in vivo and prevent teratoma formation.