Author

David A. Romero

University of TorontoORCID 0000-0002-3603-7361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Cristina H. AmoniD· 3 shared Faisal J. AlibhaiiD· 2 shared Julia E.S. Bauer· 2 shared Michael A. LaflammeiD· 2 shared Pouyan VataniiD· 2 shared Amirmahdi MostofinejadiD· 1 shared Coulter Montague· 1 shared Ferdinand AvikpeiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBioengineering

Cristina H. AmonORCID

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3 papers

Recent·Most cited

Computational fluid dynamics enables predictable scale-up of perfusion bioreactors for microvessel production

Pouyan Vatani, Kasinan Suthiwanich, Zidong Han, David A. Romero, Sara Santana Nunes, Cristina H. Amon

This paper uses computational fluid dynamics to guide the scaling of perfusion bioreactors, showing that maintaining interstitial flow ensures reproducible microvessel networks across 30-fold volume increases.

PNAS Nexus · Aug 1, 2026Peer-reviewedBioengineering

In Silico ModeIling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel Bioreactors

Ferdinand Avikpe, Faisal J. Alibhai, David A. Romero, Amirmahdi Mostofinejad, Julia E.S. Bauer, Coulter Montague, Michael A. Laflamme, Cristina H. Amon

This study develops and validates a mathematical model to predict hPSC proliferation in vertical-wheel bioreactors by incorporating shear stress and energy dissipation rate effects, achieving accurate predictions with low error rates.

bioRxiv · Apr 26, 2026 · PreprintBioengineering

Scaling-Up Vertical-Wheel Bioreactors Based on Cell Aggregate Exposure to Shear Stress and Energy Dissipation Rate

Julia E.S. Bauer, Faisal J. Alibhai, Pouyan Vatani, David A. Romero, Michael A. Laflamme, Cristina H. Amon

This paper characterizes the hydrodynamic environment in vertical-wheel bioreactors and shows that trajectory-based energy dissipation rate exposures better predict cell behavior than volume-averaged metrics.

Annals of Biomedical Engineering · Apr 14, 2026Peer-reviewedBioengineering