Author

Zisheng Fan

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Organism:human· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Mingyue ZhengiD· 2 shared Ruirui YangiD· 2 shared Sulin ZhangiD· 2 shared Xiaomin LuoiD· 2 shared Chen Zheng· 1 shared Chenmao Zhou· 1 shared Chong QiniD· 1 shared Dan TengiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Mingyue ZhengORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 12, 2026

Functional orthogonality of WRN inhibitor resistance enables alternating therapy and mutation-tolerant inhibitor design in MSI-H cancers

Guizhen Zhou, Dan Teng, Dan Wang…·Mingyue Zheng

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.

DOI 10.64898/2026.06.09.731233

humanwhole-exome sequencing

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Molecular BiologybioRxivPreprintMar 26, 2022

Drug design and repurposing with a sequence-to-drug paradigm

Lifan Chen, Zisheng Fan, Jie Chang…·Mingyue Zheng

This paper introduces a sequence-to-drug paradigm using TransformerCPI2.0 to discover drug-like molecules from protein sequences and validates its effectiveness for three targets.

1 citation

protein sequencedeep learning

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