Quasi-neutral molecular evolution -- When positive and negative selection cancel out
Bingjie Chen, Zongkun Shi, Qingjian Chen, Darryl Shibata, Haijun Wen, Chung-I Wu
The paper shows that quasi-neutral evolution, where positive and negative selection balance, is common in somatic-cell evolution, particularly in small stem cell populations, explaining higher cancer risk in the colon compared to the small intestine.
bioRxiv · May 25, 2018 · PreprintEvolutionary Biology