Author

Bingjie Chen

Sun Yat-sen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Haijun WeniD· 3 shared Chenli LiuiD· 2 shared Chung‐I WuiD· 2 shared Lingjie ZhangiD· 2 shared Miles E Tracy· 2 shared Tong Deng· 2 shared Xuemei LuiD· 2 shared Xueyu Liu· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersEvolutionary Biology

Haijun WenORCID

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3 papers

Recent·Most cited

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

Lingjie Zhang, Tong Deng, Zhongqi Liufu, Xiangnyu Chen, Shijie Wu, Xueyu Liu, Changhao Shi, Bingjie Chen, Zheng Hu, Qichun Cai, Chenli Liu, Mengfeng Li, Miles E Tracy, Xuemei Lu, Chung‐I Wu, Haijun Wen

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

eLife · Sep 5, 2024Peer-reviewedEvolutionary Biology

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

Lingjie Zhang, Tong Deng, Zhongqi Liufu, Xueyu Liu, Bingjie Chen, Zheng Hu, Chenli Liu, Miles E Tracy, Xuemei Lu, Haijun Wen, Chung‐I Wu

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

bioRxiv · May 29, 2024Evolutionary Biology

Quasi-neutral molecular evolution -- When positive and negative selection cancel out

Bingjie Chen, Zongkun Shi, Qingjian Chen, Darryl Shibata, Haijun Wen, Chung-I Wu

The paper shows that quasi-neutral evolution, where positive and negative selection balance, is common in somatic-cell evolution, particularly in small stem cell populations, explaining higher cancer risk in the colon compared to the small intestine.

bioRxiv · May 25, 2018 · PreprintEvolutionary Biology