Chung-I Wu

Genomic Evidence for Males of Exceptional Reproductive Output (ERO) in Apes and Humans

The paper uses genomic diversity data to estimate the variance ratio of reproductive output in males and females across apes and humans, finding evidence for exceptional reproductive output in some males.

Discovery of Waddington's developmental canals elucidates the embryogenesis stability in Caenorhabditis elegans

This study identifies and quantifies developmental canals in C. elegans embryogenesis that suppress noise and stabilize development, revealing how cell-level stochasticity affects phenotypic outcomes.

Quasi-neutral molecular evolution -- When positive and negative selection cancel out

The paper shows that quasi-neutral evolution, where positive and negative selection balance, is common in somatic-cell evolution, particularly in small stem cell populations, explaining higher cancer risk in the colon compared to the small intestine.

Gene regulatory network rewiring by an adaptively evolving microRNA cluster in Drosophila

This study shows how a newly evolved microRNA cluster in Drosophila rewires gene regulatory networks through sequence changes, while maintaining a conserved target pool.

From foodwebs to gene regulatory networks (GRNs) - weak repressions by microRNAs confer system stability

The paper uses foodweb theory to show weak microRNA repressions enhance gene regulatory network stability, supported by yeast and human transcriptome data and simulations.

The regulator-executor-phenotype architecture shaped by natural selection

The paper investigates how natural selection shapes the regulator-executor-phenotype architecture in yeast by analyzing morphological traits and their genetic control.

Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics

The study analyzes genetic diversity in multiple hepatocellular carcinomas, finding that low-frequency mutations pre-exist and contribute to drug resistance, presenting challenges and opportunities for cancer therapeutics.