Arek Kulczyk

This study investigates the architecture of the T7 leading-strand replisome to determine whether DNA unwinding is driven by helicase or polymerase, concluding support for the helicase-driven unwinding model.

The paper presents high-resolution structures of Helicobacter pylori TlpD, revealing how ligand-binding perturbations propagate through coiled-coils to regulate kinase interfaces.